Protein Modification Reagents
Medchemexpress LLC DSPE-PEG-folate | 95.7% | 5000 (Average) | 10 MG
DSPE-PEG-Folate, MW 5000 is a pegylated phospholipid composed of distearoyl phosphatidylethanolamine (DSPE) conjugated to polyethylene glycol terminated with folic acid. It is used to impart folate-receptor targeting to liposomes, micelles, and other nanocarriers for targeted drug delivery and receptor-specific binding studies.
- Enables folate-receptor mediated targeting of nanocarriers.
- Average PEG molecular weight of 5000 provides an extended hydrophilic spacer.
- Integrates into lipid bilayers and forms stable micelles.
- High purity suitable for research applications.
- Available in small research pack sizes for formulation studies.
Medchemexpress LLC M-PEG4-PFP ester | 2952895-31-5 | 98.0% | 402.31 | 25 MG
M-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- Molecular weight: 402.31
- Formula: C16H19F5O6
- Appearance: Liquid
- Color: Colorless to light yellow
- Solubility in DMSO: ≥ 100 mg/mL (248.56 mM)
![eMolecules Cy5-PEG5-amine HCl salt | Broadpharm |817.930 | C44H66Cl2N4O6 | 95.000 | [Cl-].[Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCOCCOCC[NH3+])c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 25mg | 263744691](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183455.JPG-250.jpg)
eMolecules Cy5-PEG5-amine HCl salt | Broadpharm |817.930 | C44H66Cl2N4O6 | 95.000 | [Cl-].[Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCOCCOCC[NH3+])c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 25mg | 263744691
Cy5-PEG5-amine HCl salt | Broadpharm |817.930 | C44H66Cl2N4O6 | 95.000 | [Cl-].[Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCOCCOCC[NH3+])c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 25mg | 263744691
Medchemexpress LLC DSPE-N3 | 2839508-98-2 | 96.4% | 831.11 g/mol | C43H83N4O9P | 50 MG
DSPE-N3 is an azide-functionalized phospholipid used as a click-chemistry reagent for biochemical research. It enables covalent conjugation via azide-alkyne cycloaddition and is commonly used to functionalize liposomes, nanoparticles, and biomolecules for labeling or targeted delivery applications.
- Contains an azide functional group for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) for copper-free reactions.
- Suitable for liposome and surface functionalization in biochemical studies.
- Supplied as a white to off-white solid with high purity.
- Soluble in DMSO (12.5 mg/mL) with sonication and heating.
- Recommend sealed storage at 4°C; in solution: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC M-PEG4-PFP ester | 2952895-31-5 | ≥98.0% | 402.31 | 100 MG
m-PEG4-PFP ester is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. These molecules are engineered to contain two distinct ligands, one binding to an E3 ubiquitin ligase and the other targeting a specific protein. This innovative design allows PROTACs to leverage the cell's ubiquitin-proteasome system for the selective degradation of target proteins.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Bromoacetamido-PEG4-NHS ester | 1260139-70-5 | 98.69% | C17H27BrN2O9 | 250 MG
Bromoacetamido-PEG4-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands joined by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PROTAC linker
- Suitable for the synthesis of PROTACs
- Intended for research use only
Medchemexpress LLC Mal-PEG3-C1-NHS ester | 2230016-26-7 | 95.0% | 384.34 | C16H20N2O9 | 5 MG
Mal-PEG3-C1-NHS ester is a non-cleavable three-unit polyethylene glycol (PEG3) linker bearing a maleimide and an N-hydroxysuccinimide (NHS) ester for conjugation to thiol and amine groups in antibody-drug conjugates. Supplied as a solid with typical purity 95.0%, it is provided with supporting documentation for safe handling and characterization.
- Non-cleavable three-unit PEG linker for stable conjugation.
- Contains maleimide and NHS ester functional groups for thiol and amine coupling.
- Molecular weight 384.34 g/mol.
- Purity 95.0%.
- CAS number 2230016-26-7 for chemical identification.
- Available in 5 mg, 10 mg, 25 mg, and 50 mg sizes; supplied for reconstitution in DMSO at indicated concentrations.
![eMolecules 1257063-35-6 | N3-PEG4-CH2CH2COOH | Acrotein ChemBio Inc. | MFCD12406155 | 291.304 | C11H21N3O6 | 97.000 | OC(=O)CCOCCOCCOCCOCCN=[N+]=[N-] | 10g | 851113878](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000482689.jpg-250.jpg)
eMolecules 1257063-35-6 | N3-PEG4-CH2CH2COOH | Acrotein ChemBio Inc. | MFCD12406155 | 291.304 | C11H21N3O6 | 97.000 | OC(=O)CCOCCOCCOCCOCCN=[N+]=[N-] | 10g | 851113878
N3-PEG4-CH2CH2COOH | Acrotein ChemBio Inc. | 1257063-35-6 | MFCD12406155 | 291.304 | C11H21N3O6 | 97.000 | OC(=O)CCOCCOCCOCCOCCN=[N+]=[N-] | 10g | 851113878
![eMolecules 2363756-50-5 | Azido-PEG12-NHS ester | Broadpharm | MFCD13184947 | 740.801 | C31H56N4O16 | 98.000 | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 296213818](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1706641.jpg-250.jpg)
eMolecules 2363756-50-5 | Azido-PEG12-NHS ester | Broadpharm | MFCD13184947 | 740.801 | C31H56N4O16 | 98.000 | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 296213818
Azido-PEG12-NHS ester | Broadpharm | 2363756-50-5 | MFCD13184947 | 740.801 | C31H56N4O16 | 98.000 | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 296213818
Medchemexpress LLC Bis-PEG9-NHS ester 100mg | 1008402-79-6 | 708.71 | C30H48N2O17 | 100 MG
Bis-PEG9-NHS ester is a homobifunctional PEG-based linker containing two N-hydroxysuccinimide (NHS) ester reactive groups, used to conjugate primary amines in proteins and small molecules. It is commonly applied as a spacer/linker in PROTAC and ADC synthesis. The reagent is supplied as a viscous liquid with high purity and is moisture sensitive; store sealed and protected from humidity.
- Homobifunctional PEG9 spacer with two NHS ester reactive termini.
- Enables efficient amine conjugation for ADCs, PROTACs, and bioconjugation.
- Hydrophilic PEG spacer improves solubility in aqueous media.
- High purity (≥98%) for reproducible conjugation performance.
- Viscous liquid; moisture sensitive-store sealed and avoid humidity.
Medchemexpress LLC BODIPY-X-Alkyne | 1173281-82-7 | 96.0% | 434.33 | 50 MG
BODIPY-X-Alkyne is an alkyne-modified BODIPY derivative with excitation at 526 nm and emission at 540 nm. It can react with azides via a copper-catalyzed click reaction.
- Alkyne-modified BODIPY derivative
- Excitation (Ex) = 525 nm
- Emission (Em) = 540 nm
- Reacts with azides via a copper-catalyzed click reaction
Medchemexpress LLC Mc-peg2-va-pab-exatecan | 2845165-13-9 | 99.6% | 994.03 | C51H56FN7O13 | 10 MG
MC-PEG2-VA-PAB-Exatecan is an exatecan-based drug-linker conjugate designed for antibody-drug conjugate (ADC) research. It links the camptothecin-derived cytotoxic payload exatecan to a cleavable PEG2-Val-Cit-PAB linker to permit targeted intracellular release of the payload during ADC development.
- Exatecan payload confers potent topoisomerase I inhibition.
- Cleavable Val-Cit-PAB linker enables enzyme-triggered release inside target cells.
- PEG2 spacer improves solubility and conjugation flexibility.
- High reported purity supports reproducible research results.
- Available in mg-scale quantities suitable for ADC synthesis workflows.
Medchemexpress LLC DMG-PEG-Mal (MW 2000) | 99.3% | 2000 (Average) | 5 MG
DMG-PEG-Mal (MW 2000) is a PEG lipid designed to enhance the delivery efficiency and tissue specificity of poorly soluble drugs. This compound is valuable for various drug delivery research applications.
- Improves delivery efficiency of poorly soluble drugs
- Enhances tissue specificity
- Suitable for drug delivery research